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Ashton, M.P.* ; Eugster, A.* ; Walther, D.* ; Daehling, N.* ; Riethausen, S. ; Kuehn, D.* ; Klingel, K.* ; Beyerlein, A. ; Zillmer, S. ; Ziegler, A.-G. ; Bonifacio, E.

Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin.

Sci. Rep. 6:32899 (2016)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Viral infections are associated with autoimmunity in type 1 diabetes. Here, we asked whether this association could be explained by variations in host immune response to a putative type 1 etiological factor, namely coxsackie B viruses (CVB). Heterogeneous antibody responses were observed against CVB capsid proteins. Heterogeneity was largely defined by different binding to VP1 or VP2. Antibody responses that were anti-VP2 competent but anti-VP1 deficient were unable to neutralize CVB, and were characteristic of children who developed early insulin-targeting autoimmunity, suggesting an impaired ability to clear CVB in early childhood. In contrast, children who developed a GAD-targeting autoimmunity had robust VP1 and VP2 antibody responses to CVB. We further found that 20% of memory CD4(+) T cells responding to the GAD65247-266 peptide share identical T cell receptors to T cells responding to the CVB4 p2C30-51 peptide, thereby providing direct evidence for the potential of molecular mimicry as a mechanism for GAD autoimmunity. Here, we highlight functional immune response differences between children who develop insulin-targeting and GAD-targeting autoimmunity, and suggest that children who lose B cell tolerance to insulin within the first years of life have a paradoxical impaired ability to mount humoral immune responses to coxsackie viruses.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Antibody Standardization Program; Glutamic-acid Decarboxylase; Cd4(+) T-cells; Islet Autoimmunity; Enterovirus Infections; Increased Risk; Early-life; Type-1; Children; Autoantibodies
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 6, Issue: , Pages: , Article Number: 32899 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)