PuSH - Publication Server of Helmholtz Zentrum München: Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of notch to inhibit neurogenesis at the midbrain-hindbrain boundary.

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Geling, A.* ; Plessy, C.* ; Rastegar, S.* ; Strähle, U.* ; Bally-Cuif, L.

Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of notch to inhibit neurogenesis at the midbrain-hindbrain boundary.

Development 131, 1993-2006 (2004)

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Neurogenesis in both vertebrates and invertebrates is tightly controlled in time and space involving both positive and negative regulators. We report here that the bHLH factor Her5 acts as a prepattern gene to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate. This involves selective suppression of both neurogenin1 (ngn1) and coe2 mRNA expression in a process that is independent of Notch signalling, and where inhibition of either ngn1 or coe2 expression is sufficient to prevent neuronal differentiation across the midbrain-hindbrain boundary. A ngn1 transgene faithfully responds to Her5 and deletion analysis of the transgene identifies an E-box in a ngn1 upstream enhancer to be required for repression by Her5. Together our data demonstrate a role of Her5 as a prepattern factor in the spatial definition of proneural domains in the zebrafish neural plate, in a manner similar to its Drosophila homologue Hairy.

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