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Open Access Green as soon as Postprint is submitted to ZB.
Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: Use of the multielectrode array as a screening strategy.
Drug Discov. Today 22, 31-42 (2017)
Hypothalamic neural circuits are recognised as primary sites of the neuromodulator effect of homeostatic food intake, whereas changes in ventral tegmental area (VTA), hippocampus and amygdala have been implicated in the hedonic, cognitive and emotional aspects of eating. Here, we discuss synaptic transmission and plasticity within brain circuits governing appetite and food intake behaviour, focusing on the metabolic hormones ghrelin and leptin. We discuss functional changes within these circuitries and critically assess the applicability of electrophysiological measurements using in vitro multielectrode array (MEA) systems to identify novel appetite modulators. Stringent validation of functional assays to screen neuroactive substrates is of crucial importance for the discovery of novel food intake modulators, with major implications for the nutraceutical food industry and drug development.
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Publication type
Article: Journal article
Document type
Review
Keywords
Electrophysiology ; Food Intake ; Ghrelin ; Hypothalamic Circuitry ; Leptin. ; Mesolimbic Reward System ; Multielectrode Array Recordings ; Neuroendocrine Factors ; Synaptic Transmission And Plasticity; Long-term Potentiation; Metabotropic Glutamate Receptors; Central-nervous-system; Hippocampal Synaptic Plasticity; Cultured Cortical Networks; Paired-pulse Facilitation; Energy-balance; Neuronal-activity; Food-intake; Arcuate Nucleus
Language
Publication Year
2017
Prepublished in Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1359-6446
e-ISSN
1878-5832
Journal
Drug discovery today
Quellenangaben
Volume: 22,
Issue: 1,
Pages: 31-42
Publisher
Elsevier
Publishing Place
Cambridge
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
PubMed ID
27634341
WOS ID
WOS:000392787800005
Scopus ID
84994780482
Erfassungsdatum
2016-09-30