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Shaban, H.* ; O'Connor, R.* ; Ovsepian, S.V. ; Dinan, T.G.* ; Cryan, J.F.* ; Schellekens, H.*

Electrophysiological approaches to unravel the neurobiological basis of appetite and satiety: Use of the multielectrode array as a screening strategy.

Drug Discov. Today 22, 31-42 (2017)

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Open Access Green as soon as Postprint is submitted to ZB.

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Hypothalamic neural circuits are recognised as primary sites of the neuromodulator effect of homeostatic food intake, whereas changes in ventral tegmental area (VTA), hippocampus and amygdala have been implicated in the hedonic, cognitive and emotional aspects of eating. Here, we discuss synaptic transmission and plasticity within brain circuits governing appetite and food intake behaviour, focusing on the metabolic hormones ghrelin and leptin. We discuss functional changes within these circuitries and critically assess the applicability of electrophysiological measurements using in vitro multielectrode array (MEA) systems to identify novel appetite modulators. Stringent validation of functional assays to screen neuroactive substrates is of crucial importance for the discovery of novel food intake modulators, with major implications for the nutraceutical food industry and drug development.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Electrophysiology ; Food Intake ; Ghrelin ; Hypothalamic Circuitry ; Leptin. ; Mesolimbic Reward System ; Multielectrode Array Recordings ; Neuroendocrine Factors ; Synaptic Transmission And Plasticity; Long-term Potentiation; Metabotropic Glutamate Receptors; Central-nervous-system; Hippocampal Synaptic Plasticity; Cultured Cortical Networks; Paired-pulse Facilitation; Energy-balance; Neuronal-activity; Food-intake; Arcuate Nucleus

ISSN (print) / ISBN 1359-6446

e-ISSN 1878-5832

Journal Drug discovery today

Quellenangaben Volume: 22, Issue: 1, Pages: 31-42

Publisher Elsevier

Publishing Place Cambridge

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)