PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Kim, S.E.* ; Zhang, L.* ; Ma, K.* ; Riegman, M.* ; Chen, F.* ; Ingold, I. ; Conrad, M. ; Turker, M.Z.* ; Gao, M.* ; Jiang, X.* ; Monette, S.* ; Pauliah, M.* ; Gonen, M.* ; Zanzonico, P.* ; Quinn, T.* ; Wiesner, U.* ; Bradbury, M.S.* ; Overholtzer, M.*

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth.

Nat. Nanotechnol. 11, 977-985 (2016)
Postprint Research data DOI PMC
Open Access Green
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10 nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
35.267
8.464
275
310
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1748-3387
e-ISSN 1748-3395
Journal Nature Nanotechnology
Quellenangaben Volume: 11, Issue: , Pages: 977-985 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
G-500500-004
DOI 10.1038/nnano.2016.164
WOS ID WOS:000387530100018
PubMed ID 27668796
Erfassungsdatum 2016-10-07
[➜Report correction]