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Open Access Green as soon as Postprint is submitted to ZB.
Functional neuroimaging studies in functional dyspepsia patients: A systematic review.
Neurogastroenterol. Mot. 28, 793-805 (2016)
Background There is increasing evidence in support of the presence of abnormal central changes (compared to healthy controls) in functional dyspepsia (FD) in addition to the peripheral changes in gastrointestinal tract. Purpose This systematic review aims to provide an integrative understanding of the abnormal functional brain activity, visceral sensation, dyspeptic symptoms, and psychological changes of FD. Electronic and hand searches were conducted to identify functional neuroimaging studies involving FD patients. Sixteen studies were selected and divided into three categories: 10 resting state studies, three visceral distention studies, and three acupuncture studies. Changes were reported in several brain areas in FD patients including the frontal cortex, somatosensory cortex, insula, anterior cingulate cortex, thalamus, hippocampus, and amygdala. These brain activity changes were associated with visceral hypersensitivity, dyspeptic symptoms, poorer quality of life, anxiety, and depression. The results show that FD is associated with functional abnormalities in sensory and pain modulation, emotion, saliency, and homeostatic processing regions. The diversity of conditions, heterogeneous results, poorly standardized diagnoses of FD, and various comorbidities may be responsible for the variability in the results.
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3.310
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Publication type
Article: Journal article
Document type
Review
Keywords
Brain Imaging ; Fmri ; Functional Dyspepsia ; Pet ; Systematic Review; Irritable-bowel-syndrome; Resting-state Fmri; Brain-gut Axis; Orbitofrontal Cortex; Acupuncture Treatment; Symptom Severity; Human Amygdala; Pet-ct; Pain; Disorders
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1350-1925
e-ISSN
1365-2982
Quellenangaben
Volume: 28,
Issue: 6,
Pages: 793-805
Publisher
Wiley
Publishing Place
Oxford [u.a.]
Reviewing status
Peer reviewed
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502400-001
WOS ID
WOS:000383290600002
Erfassungsdatum
2016-10-14