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Open Access Green as soon as Postprint is submitted to ZB.
The role of primary cilia in obesity and diabetes.
Ann. NY Acad. Sci. 1391, 71-84 (2017)
One in 12 people worldwide suffers from diabetes and more than 90% of affected adult individuals are diagnosed with type 2 diabetes mellitus (T2DM). Obesity adds to the personal risk to develop T2DM, and both metabolic diseases are rampantly increasing worldwide. Over recent years, primary cilia have moved into the focus of basic and clinical research, after several human diseases have been identified as ciliopathies (i.e., they are linked to ciliary dysfunction). A subset of ciliopathies presents with obesity and diabetes, either as core symptoms or major complications. Several studies have shown a role for ciliary signaling in the satiety signaling centers of the hypothalamus and in other metabolically active tissues, such as pancreatic islets. Here, we discuss recent advances and perspectives in ciliary metabolic research.
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4.706
1.308
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diabetes ; Insulin Signaling ; Leptin Signaling ; Obesity ; Primary Cilia ; β Cells; Bardet-biedl-syndrome; Nonsyndromic Retinitis-pigmentosa; Neuropeptide Yy2 Receptor; Body-weight; Insulin Sensitivity; Glucose-tolerance; Syndrome Proteins; Joubert Syndrome; Alstrom-syndrome; Kidney-disease
Language
english
Publication Year
2017
Prepublished in Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
0077-8923
e-ISSN
1749-6632
Quellenangaben
Volume: 1391,
Issue: 1,
Pages: 71-84
Publisher
New York Academy of Sciences
Publishing Place
Hoboken
Reviewing status
Peer reviewed
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-233
PubMed ID
27706820
WOS ID
WOS:000398806300005
Erfassungsdatum
2016-10-17