PuSH - Publication Server of Helmholtz Zentrum München: Human lysosomal acid lipase inhibitor lalistat impairs <em>Mycobacterium tuberculosis</em> growth by targeting bacterial hydrolases.

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Lehmann, J.* ; Vomacka, J.* ; Esser, K. ; Nodwell, M.* ; Kolbe, K.* ; Raemer, P.* ; Protzer, U. ; Reiling, N.* ; Sieber, S.A.*

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases.

MedChemComm 7, 1797-1801 (2016)

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	Open Access Gold (Paid Option)

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Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords 1,3-dipolar Cycloadditions; Pancreatic Lipase; Terminal Alkynes; In-vitro; Tetrahydrolipstatin; Metabolism; Susceptibility; Lipstatin; Pathogen; Dormancy

ISSN (print) / ISBN 2040-2511

e-ISSN 2040-2503

Journal MedChemComm

Quellenangaben Volume: 7, Issue: 9, Pages: 1797-1801

Publisher Royal Society of Chemistry (RSC)

Publishing Place Cambridge

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)