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Lacruz, M.E.* ; Kluttig, A.* ; Tiller, D.* ; Medenwald, D.* ; Giegling, I.* ; Rujescu, D.* ; Prehn, C. ; Adamski, J. ; Frantz, S.* ; Greiser, K.H.* ; Emeny, R.T.* ; Kastenmüller, G. ; Haerting, J.*

Cardiovascular risk factors associated with blood metabolite concentrations and their alterations over a 4-year period in a population-based cohort.

Circ. Cardiovasc. Genet. 9, 487-494 (2016)
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BACKGROUND: -The effects of lifestyle risk-factors considered collectively on the human metabolism are so far unknown. We aim to investigate the association of these risk-factors with metabolites and their changes over 4 years. METHODS AND RESULTS: -163 metabolites were measured in serum samples with the AbsoluteIDQ kit p150 (Biocrates) following a targeted metabolomics approach, in a population-based cohort of 1030 individuals, aged 45-83 at baseline. We evaluated associations between metabolite concentrations (28 acylcarnitines, 14 amino acids, 9 lyso-phosphocholines, 72 phosphocholines, 10 sphingomyelins and sum of hexoses) and 5 lifestyle risk factors (BMI, alcohol consumption, smoking, diet and exercise). Multilevel or simple linear regression modelling adjusted for relevant covariates was used for the evaluation of cross-sectional and longitudinal associations respectively, multiple testing correction was based on false discovery rate. BMI, alcohol and smoking were associated with lipid metabolism (reduced lyso- and acyl-alkyl-phosphatidylcholines and increased diacylphosphatidylcholines concentrations). Smoking showed positive associations with acylcarnitines and BMI correlated inversely with nonessential amino acids. Fewer metabolites showed relative changes that were associated with baseline risk-factors: increases in 5 different acyl-alkyl phosphatidylcholines were associated with lower alcohol consumption and BMI, and with a healthier diet. Increased levels of tyrosine were associated with BMI. Sex-specific effects of smoking and BMI were found specifically related to acylcarnitine metabolism: in women higher BMI and in men more pack-years were associated with increases in acylcarnitines. CONCLUSIONS: -This study showed sex-specific effects of lifestyle risks factors on human metabolism and highlighted their long-term metabolic consequences.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cardiovascular Disease Risk Factors ; Epidemiology ; Lifestyle ; Metabolomics; Physical-activity; Oxidative Stress; Obesity; Metabolomics; Profile; Plasma; Disease; Humans; Sphingomyelinase; Questionnaire
ISSN (print) / ISBN 1942-325X
e-ISSN 1942-3268
Journal Circulation: Cardiovascular Genetics
Quellenangaben Volume: 9, Issue: 6, Pages: 487-494 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Hagerstown, Md
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)