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Open Access Green as soon as Postprint is submitted to ZB.
Hyperpolarized multi-metal13C-sensors for magnetic resonance imaging.
Anal. Chem. 88, 10785-10789 (2016)
We introduce hyperpolarizable13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ligand-exchange Kinetics; Mri Contrast Agents; Calcium; C-13; Edta; Nmr; Probe; Ions; Sensitivity; Complexes
ISSN (print) / ISBN
0003-2700
e-ISSN
1520-6882
Journal
Analytical Chemistry
Quellenangaben
Volume: 88,
Issue: 22,
Pages: 10785-10789
Publisher
American Chemical Society (ACS)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)