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Mishra, A. ; Pariani, G. ; Oerther, T.* ; Schwaiger, M.* ; Westmeyer, G.G.

Hyperpolarized multi-metal13C-sensors for magnetic resonance imaging.

Anal. Chem. 88, 10785-10789 (2016)
Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We introduce hyperpolarizable13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ligand-exchange Kinetics; Mri Contrast Agents; Calcium; C-13; Edta; Nmr; Probe; Ions; Sensitivity; Complexes
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0003-2700
e-ISSN 1520-6882
Journal Analytical Chemistry
Quellenangaben Volume: 88, Issue: 22, Pages: 10785-10789 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30502 - Diabetes: Pathophysiology, Prevention and Therapy
30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-552000-002
G-552000-001
DOI 10.1021/acs.analchem.6b03546
WOS ID WOS:000388154700003
Scopus ID 85045584016
PubMed ID 27766840
Erfassungsdatum 2016-11-02
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