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12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: A targeted metabolomics study.
Sci. Rep. 6:37005 (2016)
Metabolomic analyses in epidemiological studies have demonstrated a strong sexual dimorphism for most metabolites. Cross-sex hormone treatment (CSH) in transgender individuals enables the study of metabolites in a cross-gender setting. Targeted metabolomic profiling of serum of fasting transmen and transwomen at baseline and following 12 months of CSH (N = 20/group) was performed. Changes in 186 serum metabolites and metabolite ratios were determined by targeted metabolomics analysis based on ESI-LC-MS/MS. RandomForest (RF) analysis was applied to detect metabolites of highest interest for grouping of transwomen and transmen before and after initiation of CSH. Principal component analysis (PCA) was performed to check whether group differentiation was achievable according to these variables and to see if changes in metabolite levels could be explained by a priori gender differences. PCA predicted grouping of individuals-determined by the citrulline/arginine-ratio and the amino acids lysine, alanine and asymmetric dimethylarginine - in addition to the expected grouping due to changes in sex steroids and body composition. The fact that most of the investigated metabolites did, however, not change, indicates that the majority of sex dependent differences in metabolites reported in the literature before may primarily not be attributable to sex hormones but to other gender-differences.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Nitric-oxide Synthase; To-male Transsexuals; Asymmetric Dimethylarginine Adma; Coronary-heart-disease; Postmenopausal Women; Replacement Therapy; Cardiovascular Risk; Plasma-levels; Follow-up; Hypogonadal Men
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Journal
Scientific Reports
Quellenangaben
Volume: 6,
Article Number: 37005
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Epidemiology II (EPI2)
Institute of Experimental Genetics (IEG)
Institute of Epidemiology II (EPI2)
Institute of Experimental Genetics (IEG)