PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Eisenberg, T.* ; Abdellatif, M.* ; Schroeder, S.* ; Primessnig, U.* ; Stekovic, S.* ; Pendl, T.* ; Harger, A.* ; Schipke, J.* ; Zimmermann, A.* ; Schmidt, A.* ; Tong, M.* ; Ruckenstuhl, C.* ; Dammbrueck, C.* ; Gross, A.S.* ; Herbst, V.* ; Magnes, C.* ; Trausinger, G.* ; Narath, S.* ; Meinitzer, A.* ; Hu, Z.* ; Kirsch, A.* ; Eller, K.* ; Carmona-Gutierrez, D.* ; Büttner, S.* ; Pietrocola, F.* ; Knittelfelder, O.* ; Schrepfer, E.* ; Rockenfeller, P.* ; Simonini, C.* ; Rahn, A.* ; Horsch, M. ; Moreth, K. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Neff, F. ; Janik, D. ; Rathkolb, B. ; Rozman, J. ; Hrabě de Angelis, M. ; Moustafa, T.* ; Haemmerle, G.* ; Mayr, M.* ; Willeit, P.* ; von Frieling-Salewsky, M.* ; Pieske, B.* ; Scorrano, L.* ; Pieber, T.R.* ; Pechlaner, R.* ; Willeit, J.* ; Sigrist, S.J.* ; Linke, W.A.* ; Mühlfeld, C.* ; Sadoshima, J.* ; Dengjel, J.* ; Kiechl, S.* ; Kroemer, G.* ; Sedej, S.* ; Madeo, F.*

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Nat. Med. 22, 1428-1438 (2016)
Postprint Research data DOI
Open Access Green
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
30.357
5.242
442
598
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Preserved Ejection Fraction; Diastolic Heart-failure; Tandem Mass-spectrometry; Salt-sensitive Rats; Pressure-overload; Amino-acids; Arginine Bioavailability; Mitochondrial Autophagy; Myocardial Hypertrophy; Robust Quantification
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Journal Nature medicine
Quellenangaben Volume: 22, Issue: 12, Pages: 1428-1438 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Pathology (PATH)
POF-Topic(s) 30201 - Metabolic Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-500600-001
G-500600-004
G-500600-005
G-500300-001
G-500600-006
G-500692-001
DOI 10.1038/nm.4222
WOS ID WOS:000389549000020
Erfassungsdatum 2016-11-18
[➜Report correction]