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Mishra, A. ; Jiang, Y. ; Roberts, S. ; Ntziachristos, V. ; Westmeyer, G.G.

Near-infrared photoacoustic imaging probe responsive to calcium.

Anal. Chem. 88, 10790-10794 (2016)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.
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Publication type Article: Journal article
Document type Scientific Article
Keywords In-vivo; Optoacoustic Tomography; Mouse-brain; Red; Visualization; Magnesium; Ions; Mg2+; Time; Nmr
ISSN (print) / ISBN 0003-2700
e-ISSN 1520-6882
Journal Analytical Chemistry
Quellenangaben Volume: 88, Issue: 22, Pages: 10790-10794 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)