Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Postprint
Research data
DOI
 |
Open Access Green |
as soon as is submitted to ZB.
From profiles to function in epigenomics.
Nat. Rev. Genet. 18, 51-66 (2017)
Myriads of epigenomic features have been comprehensively profiled in health and disease across cell types, tissues and individuals. Although current epigenomic approaches can infer function for chromatin marks through correlation, it remains challenging to establish which marks actually have causative roles in gene regulation and other processes. After revisiting how classical approaches have addressed this question in the past, we discuss the current state of epigenomic profiling and how functional information can be indirectly inferred. We also present new approaches that promise definitive functional answers, which are collectively referred to as 'epigenome editing'. In particular, we explore CRISPR-based technologies for single-locus and multi-locus manipulation. Finally, we discuss which level of function can be achieved with each approach and introduce emerging strategies for high-throughput progression from profiles to function.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Chromatin analysis; CRISPR-Cas systems; DNA methylation; Epigenetics; Epigenomics; Gene regulation; Genetic engineering; Histone post-translational modifications; Targeted Dna Methylation; De-novo Methylation; Epigenetic Regulation; Gene-expression; Transcriptional Regulation; Histone Deacetylase-1; Mammalian Development; Cell Differentiation; Early Embryogenesis; Lysine Methylation
ISSN (print) / ISBN
1471-0056
e-ISSN
1471-0064
Journal
Nature Reviews - Genetics
Quellenangaben
Volume: 18,
Issue: 1,
Pages: 51-66
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)