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Regina, B.F.* ; Gladyshev, V.N.* ; Arner, E.S.J.* ; Berry, M.J.* ; Bruford, E.A.* ; Burk, R.F.* ; Carlson, B.A.* ; Castellano, S.* ; Chavatte, L.* ; Conrad, M. ; Copeland, P.R.* ; Diamond, A.M.* ; Driscoll, D.M.* ; Ferreiro, A.* ; Flohé, L.* ; Green, F.R.* ; Guigo, R.* ; Handy, D.E.* ; Hatfield, D.L.* ; Hesketh, J.* ; Hoffmann, P.R.* ; Holmgren, A.* ; Hondal, R.J.* ; Howard, M.T.* ; Huang, K.M.* ; Kim, H.Y.* ; Kim, I.Y.* ; Köhrle, J.* ; Krol, A.* ; Kryukov, G.V.* ; Lee, B.J.* ; Lee, B.C.* ; Lei, X.G.* ; Liu, Q.* ; Lescure, A.* ; Lobanov, A.V.* ; Loscalzo, J.* ; Maiorino, M.* ; Mariotti, M.* ; Prabhu, K.S.* ; Rayman, M.P.* ; Rozovsky, S.* ; Salinas, G.* ; Schmidt, E.E.* ; Schomburg, L.* ; Schweizer, U.* ; Simonović, M.* ; Sunde, R.A.* ; Tsuji, P.A.* ; Tweedie, S.* ; Ursini, F.F.* ; Whanger, P.D.* ; Zhang, Y.*

Selenoprotein gene nomenclature.

J. Biol. Chem. 291, 24036-24040 (2016)
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The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords function; gene name; genomics; nomenclature; selenium; selenocysteine; selenoprotein; structure-function; Hydroperoxide Glutathione-peroxidase; Amino-acid-sequence; Thioredoxin Reductase; Rat-liver; Iodothyronine 5-deiodinase; Eukaryotic Selenoproteins; Selenium Metabolism; Containing Proteins; Messenger-rna; Selenocysteine
ISSN (print) / ISBN 0021-9258
e-ISSN 1083-351X
Journal Journal of Biological Chemistry, The
Quellenangaben Volume: 291, Issue: 46, Pages: 24036-24040 Article Number: , Supplement: ,
Publisher American Society for Biochemistry and Molecular Biology
Publishing Place Bethesda
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)