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Selenoprotein gene nomenclature.
J. Biol. Chem. 291, 24036-24040 (2016)
The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
function; gene name; genomics; nomenclature; selenium; selenocysteine; selenoprotein; structure-function; Hydroperoxide Glutathione-peroxidase; Amino-acid-sequence; Thioredoxin Reductase; Rat-liver; Iodothyronine 5-deiodinase; Eukaryotic Selenoproteins; Selenium Metabolism; Containing Proteins; Messenger-rna; Selenocysteine
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
0021-9258
e-ISSN
1083-351X
Quellenangaben
Volume: 291,
Issue: 46,
Pages: 24036-24040
Publisher
American Society for Biochemistry and Molecular Biology
Publishing Place
Bethesda
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-004
WOS ID
WOS:000388498100020
Scopus ID
84995487883
PubMed ID
27645994
Erfassungsdatum
2016-12-01