PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Fehm, T. ; Dean-Ben, X.L. ; Ford, S.J. ; Razansky, D.

In vivo whole-body optoacoustic scanner with real-time volumetric imaging capacity.

Optica 3, 1153-1159 (2016)
Publ. Version/Full Text Research data DOI
Open Access Gold
Accurate visualization of biological events occurring on a sub-second scale requires high frame rate acquisition of image data from living tissues. Yet,fast imaging performance commonly comes at the cost of limited field-of-view and reduced image quality. Here,we report on a small-animal optoacoustic tomographic imaging concept based on scanning of a spherical detection array. The suggested approach delivers whole-body images of unparalleled quality while retaining real-time volumetric imaging capability within selected regions at the whole organ scale. Imaging performance was tested in tissue-mimicking phantoms and living animals,attaining nearly isotropic three-dimensional spatial resolution in the range of 250-500 µm across fields of view covering the entire mouse body. The system maintained high volumetric imaging rates of 100 frames per second within volumes of up to 1.5 cm3,which further allowed visualizing the fast motion of a beating mouse heart without gating the acquisition. The newly introduced approach is ideally suited for acquisition of both real-time and whole-body volumetric image data,thus offering powerful capacities for simultaneous anatomical,functional,and molecular imaging with optoacoustics.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.205
2.779
35
44
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords (110.5120) Photoacoustic Imaging ; (110.6955) Tomographic Imaging ; (140.3490) Lasers,distributed-feedback ; (170.2655) Functional Monitoring And Imaging; Photoacoustic Computed-tomography; Thermoacoustic Tomography; Brain; Microscopy; Perfusion; Feedback; Array; Msot
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 2334-2536
Journal Optica
Quellenangaben Volume: 3, Issue: 11, Pages: 1153-1159 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Publishing Place Washington, DC
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505590-001
DOI 10.1364/OPTICA.3.001153
WOS ID WOS:000388975200001
Scopus ID 84996503980
Erfassungsdatum 2016-12-12
[➜Report correction]