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Ried, J.S. ; Jeff, J.M.* ; Chu, A.Y.* ; Bragg-Gresham, J.L.* ; van Dongen, J.* ; Huffman, J.E.* ; Ahluwalia, T.S.* ; Cadby, G.* ; Eklund, N.* ; Eriksson, J.* ; Esko, T.* ; Feitosa, M.F.* ; Goel, A.* ; Gorski, M.* ; Hayward, C.* ; Heard-Costa, N.L.* ; Jackson, A.U.* ; Jokinen, E.* ; Kanoni, S.* ; Kristiansson, K.* ; Kutalik, Z.* ; Lahti, J.* ; Luan, J.* ; Mägi, R.* ; Mahajan, A.* ; Mangino, M.* ; Medina-Gomez, C.* ; Monda, K.L.* ; Nolte, I.M.* ; Perusse, L.* ; Prokopenko, I.* ; Qi, L.* ; Rose, L.M.* ; Salvi, E.* ; Smith, M.T.* ; Snieder, H.* ; Standáková, A.* ; Ju Sung, Y.* ; Tachmazidou, I.* ; Teumer, A.* ; Thorleifsson, G.* ; van der Harst, P.* ; Lichtner, P. ; Gieger, C. ; Loos, R.J.F.* ; Willems, S.M.* ; Wong, A.* ; Zhang, W.* ; Albrecht, E. ; Couto Alves, A.* ; Bakker, S.J.L.* ; Barlassina, C.* ; Bartz, T.M.* ; Beilby, J.* ; Bellis, C.* ; Bergman, R.N.* ; Bergmann, S.* ; Blangero, J.* ; Blüher, M.* ; Boerwinkle, E.* ; Bonnycastle, L.L.* ; Bornstein, S.R.* ; Bruinenberg, M.* ; Campbell, H.* ; Döring, A. ; Grallert, H. ; Strauch, K. ; Peters, A. ; Heid, I.M. ; Müller-Nurasyid, M.

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Nat. Commun. 7:13357 (2016)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Genome-wide Association; Diet-induced Obesity; Mass Index; Disease Associations; Fat Distribution; Early-onset; Hip Ratio; Resource; Biology; Height
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 7, Issue: , Pages: , Article Number: 13357 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Institute of Human Genetics (IHG)