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Marioni, R.E.* ; Ritchie, S.J.* ; Joshi, P.K.* ; Hagenaars, S.P.* ; Okbay, A.* ; Fischer, K.* ; Adams, M.* ; Hill, W.* ; Davies, G.* ; Nagy, R.* ; Amador, C.* ; Läll, K.* ; Metspalu, A.* ; Liewald, D.C.* ; Campbell, A.* ; Wilson, J.F.* ; Hayward, C.* ; Esko, T.* ; Porteous, D.J.* ; Gale, C.R.* ; Deary, I.J.* ; EUMODIC Consortium (Baumbach, C. ; Gieger, C. ; Meisinger, C. ; Lichtner, P. ; Meitinger, T. ; Strauch, K.)

Genetic variants linked to education predict longevity.

Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
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Open Access Gold
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords genetics: education: longevity: prediction: polygenic score
Language
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 113, Issue: 47, Pages: 13366-13371 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-504000-006
G-504091-004
G-500700-001
DOI 10.1073/pnas.1605334113
Erfassungsdatum 2016-12-20
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