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Wang, L.* ; Heckman, M.G.* ; Aasly, J.O.* ; Annesi, G.* ; Bozi, M.* ; Chung, S.J.* ; Clarke, C.* ; Crosiers, D.* ; Eckstein, G.N. ; Garraux, G.* ; Hadjigeorgiou, G.M.* ; Hattori, N.* ; Jeon, B.* ; Kim, Y.J.* ; Kubo, M.* ; Lesage, S.* ; Lin, J.J.* ; Lynch, T.* ; Lichtner, P. ; Mellick, G.D.* ; Mok, V.* ; Morrison, K.E.* ; Quattrone, A.* ; Satake, W.* ; Silburn, P.A.* ; Stefanis, L.* ; Stockton, J.D.* ; Tan, E.K.* ; Toda, T.* ; Brice, A.* ; van Broeckhoven, C.* ; Uitti, R.J.* ; Wirdefeldt, K.* ; Wszolek, Z.* ; Xiromerisiou, G.* ; Maraganore, D.M.* ; Gasser, T.* ; Kruger, R.* ; Farrer, M.J.* ; Ross, O.A.* ; Sharma, M.*

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: Analysis of a large multicenter study.

Neurobiol. Aging 49, 217.e1-217.e4 (2017)
Postprint Research data DOI PMC
Open Access Green
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genetic Epidemiology ; Lrrk2 ; Park16 ; Parkinson's Disease
Language english
Publication Year 2017
Prepublished in Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Journal Neurobiology of Aging
Quellenangaben Volume: 49, Issue: , Pages: 217.e1-217.e4 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
DOI 10.1016/j.neurobiolaging.2016.09.022
WOS ID WOS:000393977700029
Scopus ID 85002145842
PubMed ID 27814993
Erfassungsdatum 2016-12-31
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