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Wang, L.* ; Heckman, M.G.* ; Aasly, J.O.* ; Annesi, G.* ; Bozi, M.* ; Chung, S.J.* ; Clarke, C.* ; Crosiers, D.* ; Eckstein, G.N. ; Garraux, G.* ; Hadjigeorgiou, G.M.* ; Hattori, N.* ; Jeon, B.* ; Kim, Y.J.* ; Kubo, M.* ; Lesage, S.* ; Lin, J.J.* ; Lynch, T.* ; Lichtner, P. ; Mellick, G.D.* ; Mok, V.* ; Morrison, K.E.* ; Quattrone, A.* ; Satake, W.* ; Silburn, P.A.* ; Stefanis, L.* ; Stockton, J.D.* ; Tan, E.K.* ; Toda, T.* ; Brice, A.* ; van Broeckhoven, C.* ; Uitti, R.J.* ; Wirdefeldt, K.* ; Wszolek, Z.* ; Xiromerisiou, G.* ; Maraganore, D.M.* ; Gasser, T.* ; Kruger, R.* ; Farrer, M.J.* ; Ross, O.A.* ; Sharma, M.*

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: Analysis of a large multicenter study.

Neurobiol. Aging 49, 217.e1-217.e4 (2017)

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A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Genetic Epidemiology ; Lrrk2 ; Park16 ; Parkinson's Disease

ISSN (print) / ISBN 0197-4580

e-ISSN 1558-1497

Journal Neurobiology of Aging

Quellenangaben Volume: 49, Pages: 217.e1-217.e4

Publisher Elsevier

Publishing Place New York, NY [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Human Genetics (IHG)