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Open Access Green as soon as Postprint is submitted to ZB.
Epigenetics and control of RNAs.
Methods Mol. Biol. 1488, 217-237 (2017)
Histone modifications are epigenetic marks that fundamentally impact the regulation of gene expression. Integrating histone modification information in the analysis of gene expression traits (eQTL mapping) has been shown to significantly enhance the prediction of eQTLs. In this chapter, we describe (1) how to perform quantitative trait locus (QTL) analysis using histone modification levels as traits and (2) how to integrate these data with information on RNA expression for the elucidation of the epigenetic control of transcript levels. We will provide a comprehensive introduction into the topic, describe in detail how ChIP-seq data are analyzed and elaborate on how to integrate ChIP-seq and RNA-seq data from a segregating disease animal model for the identification of the epigenetic control of RNA expression.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chip-seq ; Histone Modifications ; Integrative Analysis ; Qtl Mapping ; Recombinant Inbred Panel ; Rna Expression
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Book Volume Title
Systems Genetics
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 1488,
Pages: 217-237
Publisher
Springer
Publishing Place
Berlin [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)