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What do reactive fragments actually do in cells?
Angew. Chem.-Int. Edit. 56, 446-448 (2017)
Covalently binding molecules are frequently regarded as being generally promiscuous. In a recent study, binding selectivities and cellular target proteins of a wide variety of reactive fragments are examined in a proteome-wide context.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Covalent Fragments ; Proteomics ; Target Identification; Covalent Drugs; Discovery; Inhibitors; Docking; Design
ISSN (print) / ISBN
1433-7851
e-ISSN
1521-3773
Quellenangaben
Volume: 56,
Issue: 2,
Pages: 446-448
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Medicinal Chemistry (IMC)