PuSH - Publication Server of Helmholtz Zentrum München: LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Piccoli, G. ; Condliffe, S.B.* ; Bauer, M. ; Giesert, F. ; Boldt, K. ; de Astis, S.* ; Meixner, A. ; Sarioglu, H. ; Vogt Weisenhorn, D.M. ; Wurst, W. ; Gloeckner, C.J. ; Matteoli, M.* ; Sala, C.* ; Ueffing, M.

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

J. Neurosci. 31, 2225-2237 (2011)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of Parkinson's disease mainly because of the lack of knowledge about the physiological role of LRRK2. To determine the function of LRRK2, we studied the impact of short hairpin RNA-mediated silencing of LRRK2 expression in cortical neurons. Paired recording indicated that LRRK2 silencing affects evoked postsynaptic currents. Furthermore, LRRK2 silencing induces at the presynaptic site a redistribution of vesicles within the bouton, altered recycling dynamics, and increased vesicle kinetics. Accordingly, LRRK2 protein is present in the synaptosomal compartment of cortical neurons in which it interacts with several proteins involved in vesicular recycling. Our results suggest that LRRK2 modulates synaptic vesicle trafficking and distribution in neurons and in consequence participates in regulating the dynamics between vesicle pools inside the presynaptic bouton.

Altmetric

Additional Metrics?

[➜Log in]