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Open Access Green as soon as Postprint is submitted to ZB.
In situ metabolomics in cancer by mass spectrometry imaging.
Adv. Cancer Res. 134, 117-132 (2017)
Metabolomics is a rapidly evolving and a promising research field with the expectation to improve diagnosis, therapeutic treatment prediction, and prognosis of particular diseases. Among all techniques used to assess the metabolome in biological systems, mass spectrometry imaging is the method of choice to qualitatively and quantitatively analyze metabolite distribution in tissues with a high spatial resolution, thus providing molecular data in relation to cancer histopathology. The technique is ideally suited to study tissues molecular content and is able to provide molecular biomarkers or specific mass signatures which can be used in classification or the prognostic evaluation of tumors. Recently, it was shown that FFPE tissue samples are also suitable for metabolic analyses. This progress in methodology allows access to a highly valuable resource of tissues believed to widen and strengthen metabolic discovery-driven studies.
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Times Cited
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6.267
1.801
15
16
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diagnostic ; Ffpe Tissue ; Maldi ; Mass Spectrometry Imaging ; Metabolomics ; Predictive ; Prognostic Pathology; Predictive Molecular Pathology; Intratumor Heterogeneity; Breast-cancer; Biomarker Discovery; Clinical-relevance; Tissue-sections; Gastric-cancer; Diagnosis; Tumors; Cells
Language
english
Publication Year
2017
Prepublished in Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
0065-230x
Journal
Advances in Cancer Research
Quellenangaben
Volume: 134,
Pages: 117-132
Publisher
Elsevier
Publishing Place
San Diego
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical Pathology (AAP)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-500390-001
WOS ID
WOS:000403247100006
Scopus ID
85008225573
Erfassungsdatum
2016-12-31