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Khan, A.* ; Dellago, H.* ; Terlecki-Zaniewicz, L.* ; Karbiener, M.* ; Weilner, S.* ; Hildner, F.* ; Steininger, V.* ; Gabriel, C.* ; Mück, C.* ; Jansen-Dürr, P.* ; Hacobian, A.* ; Scheideler, M. ; Grillari-Voglauer, R.* ; Schosserer, M.* ; Grillari, J.*

SNEVhPrp19/hPso4 regulates adipogenesis of human adipose stromal cells.

Stem Cell Rep. 8, 21-29 (2017)
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Open Access Gold
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Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process.
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Publication type Article: Journal article
Document type Scientific Article
Keywords SNEV, Prp19, Pso4, adipogenesis, DNA damage repair, WRN, human adipose stromal cells, C. elegans; Mesenchymal Stem-cells; Life-span; Caenorhabditis-elegans; Dna-damage; Adipocyte Differentiation; Protein Complex; Fat; Repair; Pso4; Snev
Language
Publication Year 2017
Prepublished in Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 2213-6711
Journal Stem Cell Reports
Quellenangaben Volume: 8, Issue: 1, Pages: 21-29 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Maryland Heights, MO
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-252
DOI 10.1016/j.stemcr.2016.12.001
WOS ID WOS:000396354800003
Scopus ID 85009088620
Erfassungsdatum 2016-12-31
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