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Loft, A. ; Forss, I.* ; Mandrup, S.*

Genome-wide insights into the development and function of thermogenic adipocytes.

Trends Endocrinol. Metab. 28, 104-120 (2017)
Postprint DOI PMC
Open Access Green
Brown and brown-like adipocytes are specialized adipocytes with a high capacity to convert metabolic energy to heat. This function is not only eminent in supporting organismal thermogenesis, but may also have potential in the fight against obesity. The latter has spurred a massive interest in understanding the development and regulation of these thermogenic adipocytes. Here, we review how genome-wide studies based on next-generation sequencing have provided insight into how the chromatin and transcriptional landscapes are established in thermogenic adipocytes and how thermogenic signals can change the genomic programming of white adipocytes. Furthermore, we discuss how the integration of genomic data can be used to discover novel transcriptional pathways that may be modulated as part of therapeutic strategies for the treatment of obesity. The development and thermogenic functions of brown adipocytes are regulated by coordinated actions of many different transcription factors, cofactors, noncoding RNAs, and histone modifiers.Activation of thermogenic transcriptional regulators can change the genomic programming of white adipocytes and lead to the formation of brown-like adipocytes.Integrative genomic approaches allow deciphering of the transcriptional networks that control the development and specialized functions of thermogenic adipocytes.Integrative genomic approaches may reveal novel transcriptional pathways that can be targeted to increase the thermogenic capacity of adipocytes.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Adipocyte Browning ; Adipogenesis ; Brown Adipocyte ; Genome-wide Analysis ; Next-generation Sequencing ; Transcription Factor Network; Brown Adipose-tissue; Activated Receptor-gamma; Gene-expression; Ppar-gamma; Energy-expenditure; White Fat; Transcription Factor; Beige Adipocytes; Super-enhancers; Cold-exposure
ISSN (print) / ISBN 1043-2760
e-ISSN 1879-3061
Journal Trends in Endocrinology and Metabolism
Quellenangaben Volume: 28, Issue: 2, Pages: 104-120 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)