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Transfer factor for carbon monoxide in patients with COPD and diabetes: Results from the German COSYCONET cohort.
Respir. Res. 18:14 (2017)
Background: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. Methods: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication. Pairwise comparisons between groups and multivariate regression models were used to identify variables predicting the CO transfer factor (TLCO%pred) and the transfer coefficient (KCO%pred). Results: COPD patients with diabetes differed from those without diabetes regarding lung function, anthropometric, clinical and laboratory parameters. Moreover, gender was an important covariate. After correction for lung function, gender and body mass index (BMI), TLCO%pred did not significantly differ between patients with and without diabetes. The results for the transfer coefficient KCO were similar, demonstrating an important role of the confounding factors RV%pred, TLC%pred, ITGV%pred, FEV1%pred, FEV1/FVC, age, packyears, creatinine and BMI. There was not even a tendency towards lower values in diabetes. Conclusion: The analysis of data from a COPD cohort showed no significant differences of CO transport parameters between COPD patients with and without diabetes, if BMI, gender and the reduction in lung volumes were taken into account. This result is in contrast to observations in lung-healthy subjects with diabetes and raises the question which factors, among them potential anti-inflammatory effects of anti-diabetes medication are responsible for this finding.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Copd ; Diabetes ; Diffusing Capacity ; Lung Function; Obstructive Pulmonary-disease; Factor-kappa-b; Reference Values; Lung-function; Metformin; Inflammation; Mellitus; Macrophages; Mortality; Capacity
Language
english
Publication Year
2017
Prepublished in Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1465-9921
e-ISSN
1465-993X
Journal
Respiratory Research
Quellenangaben
Volume: 18,
Article Number: 14
Publisher
BioMed Central
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Health Economics and Health Care Management (IGM)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
80000 - German Center for Lung Research
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-505300-002
G-503900-003
G-501800-533
G-501800-391
G-503900-003
G-501800-533
G-501800-391
PubMed ID
28086884
WOS ID
WOS:000393830000001
Scopus ID
85009424111
Erfassungsdatum
2016-12-31