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Covalently circularized nanodiscs for studying membrane proteins and viral entry.
Nat. Methods 14, 49-52 (2017)
We engineered covalently circularized nanodiscs (cNDs) which, compared with standard nanodiscs, exhibit enhanced stability, defined diameter sizes and tunable shapes. Reconstitution into cNDs enhanced the quality of nuclear magnetic resonance spectra for both VDAC-1, a beta-barrel membrane protein, and the G-protein-coupled receptor NTR1, an alpha-helical membrane protein. In addition, we used cNDs to visualize how simple, nonenveloped viruses translocate their genomes across membranes to initiate infection.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Phospholipid-bilayer Nanodiscs; Scaffold Proteins; Cell Entry; Poliovirus; Receptor; Reconstitution; Particles; Virus
ISSN (print) / ISBN
1548-7091
e-ISSN
1548-7105
Journal
Nature Methods
Quellenangaben
Volume: 14,
Issue: 1,
Pages: 49-52
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)