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Karalay, O.* ; Doberauer, K. ; Vadodaria, K.C.* ; Knobloch, M.* ; Berti, L. ; Miquelajauregui, A.* ; Schwark, M.* ; Jagasia, R.* ; Taketo, MM.* ; Tarabykin, V.* ; Lie, D.C. ; Jessberger, S.*

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis.

Proc. Natl. Acad. Sci. U.S.A. 108, 5807-5812 (2011)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Neural stem cells (NSCs) generate new granule cells throughout life in the mammalian hippocampus. Canonical Wnt signaling regulates the differentiation of NSCs towards the neuronal lineage. Here we identified the prospero-related homeodomain transcription factor Prox1 as a target of β-catenin-TCF/LEF signaling in vitro and in vivo. Prox1 overexpression enhanced neuronal differentiation whereas shRNA-mediated knockdown of Prox1 impaired the generation of neurons in vitro and within the hippocampal niche. In contrast, Prox1 was not required for survival of adult-generated granule cells after they had matured, suggesting a role for Prox1 in initial granule cell differentiation but not in the maintenance of mature granule cells. The data presented here characterize a molecular pathway from Wnt signaling to a transcriptional target leading to granule cell differentiation within the adult brain and identify a stage-specific function for Prox1 in the process of adult neurogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Neural stem-cells; Dentate gyrus; Neuronal differentiation; Stem/progenitor cells; Expression Patterns; Mouse brain; In-vivo; Lineage; Mice; Maturation
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 108, Issue: 14, Pages: 5807-5812 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500590-001
PubMed ID 21436036
DOI 10.1073/pnas.1013456108
Scopus ID 79955025124
Erfassungsdatum 2011-09-14
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