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Speliotes, E.K.* ; Yerges-Armstrong, L.M.* ; Wu, J.* ; Hernaez, R.* ; Kim, L.J.* ; Palmer, C.D.* ; Gudnason, V.* ; Eiriksdottir, G.* ; Garcia, M.E.* ; Launer, L.J.* ; Nalls, M.A.* ; Clark, J.M.* ; Mitchell, B.D.* ; Shuldiner, A.R.* ; Butler, J.L.* ; Tomas, M.* ; Hoffmann, U.* ; Hwang, S.J.* ; Massaro, J.M.* ; O'Donnell, C.J.* ; Sahani, D.V.* ; Salomaa, V.* ; Schadt, E.E.* ; Schwartz, S.M.* ; Siscovick, D.S.* ; NASH Clinical Research Network (*) ; GIANT Consortium (Heid, I.M. ; Thiering, E. ; Gieger, C. ; Grallert, H. ; Meitinger, T. ; Heinrich, J. ; Illig, T. ; Peters, A. ; Wichmann, H.-E.) ; MAGIC Investigators (Grallert, H. ; Meisinger, C. ; Thorand, B. ; Wichmann, H.-E. ; Gieger, C. ; Illig, T.) ; Voight, B.F.* ; Carr, J.J.* ; Feitosa, M.F.* ; Harris, T.B.* ; Fox, C.S.* ; Smith, A.V.* ; Kao, W.H.* ; Hirschhorn, J.N.* ; Borecki, I.B.* ; GOLD Consortium (*)

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.

PLoS Genet. 7:e1001324 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
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Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ∼2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p<5×10(-8)) in or near PNPLA3, NCAN, and PPP1R3B. We genotype these and 42 other top CT hepatic steatosis-associated SNPs in 592 subjects with biopsy-proven NAFLD from the NASH Clinical Research Network (NASH CRN). In comparisons with 1,405 healthy controls from the Myocardial Genetics Consortium (MIGen), we observe significant associations with histologic NAFLD at variants in or near NCAN, GCKR, LYPLAL1, and PNPLA3, but not PPP1R3B. Variants at these five loci exhibit distinct patterns of association with serum lipids, as well as glycemic and anthropometric traits. We identify common genetic variants influencing CT-assessed steatosis and risk of NAFLD. Hepatic steatosis associated variants are not uniformly associated with NASH/fibrosis or result in abnormalities in serum lipids or glycemic and anthropometric traits, suggesting genetic heterogeneity in the pathways influencing these traits.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords coronary-artery-disease; triglyceride levels; loci; heart; risk; design; adults; steatohepatitis; pnpla3; susceptibility
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Journal PLoS Genetics
Quellenangaben Volume: 7, Issue: 3, Pages: , Article Number: e1001324 Supplement: ,
Publisher Public Library of Science (PLoS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Research Unit Molecular Epidemiology (AME)
Institute of Human Genetics (IHG)