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TEDDY Study Group (Hummel, S. ; Beyerlein, A. ; Ziegler, A.-G.) ; Tamura, R.* ; Uusitalo, U.* ; Aronsson, C.A.* ; Yang, J.* ; Riikonen, A.* ; Lernmark, A.* ; Rewers, M.J.* ; Hagopian, W.A.* ; She, J.-X.* ; Simell, O.G.* ; Toppari, J.* ; Akolkar, B.* ; Krischer, J.P.* ; Virtanen, S.M.* ; Norris, J.M.*

First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study.

Diabetes Care 40, 398-404 (2017)
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Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow's milk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS: In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding ≥3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow's milk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS: These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Kidney-disease; Nephropathy; Progression; Prediction; Protein; Esrd
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 40, Issue: 2, Pages: 398-404 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)