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Shumilov, A.* ; Tsai, M.H.* ; Schlosser, Y.T.* ; Kratz, A.S.* ; Bernhardt, K.* ; Fink, S.* ; Mizani, T.* ; Lin, X.* ; Jauch, A.* ; Mautner, J. ; Kopp-Schneider, A.* ; Feederle, R. ; Hoffmann, I.* ; Delecluse, H.J.*

Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.

Nat. Commun. 8:14257 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Comparative Genomic Hybridization; Posttransplant Lymphoproliferative Disorders; Cell-cycle Checkpoints; Nasopharyngeal Carcinoma; Infectious-mononucleosis; Cytogenetic Characterization; Endosomal Compartment; Extra Centrosomes; Hodgkins-lymphoma; Dna-damage
Language english
Publication Year 2017
Prepublished in Year 318
HGF-reported in Year 2017
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 14257 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)
CF Monoclonal Antibodies (CF-MAB)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30201 - Metabolic Health
Research field(s) Immune Response and Infection
Helmholtz Diabetes Center
PSP Element(s) G-501500-001
G-502210-001
PubMed ID 28186092
DOI 10.1038/ncomms14257
WOS ID WOS:000393656300001
Scopus ID 85012173092
Erfassungsdatum 2017-02-27
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