PuSH - Publication Server of Helmholtz Zentrum München: Cinnamon: Does it hold its promises in cows? Using non-targeted blood serum metabolomics profiling to test the effects of feeding cinnamon to dairy cows undergoing lactation-induced insulin resistance.

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Sadri, H.* ; Alizadeh, A.R.* ; Vakili, H.* ; Ghorbani, A.* ; Bruckmaier, R.M.* ; Artati, A. ; Adamski, J. ; Sauerwein, H.P.*

Cinnamon: Does it hold its promises in cows? Using non-targeted blood serum metabolomics profiling to test the effects of feeding cinnamon to dairy cows undergoing lactation-induced insulin resistance.

Metabolomics 13:28 (2017)

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Open Access Green as soon as Postprint is submitted to ZB.

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Introduction: Cinnamon exerts insulin-enhancing activity in vitro and was demonstrated to improve blood glucose and lipid profiles in several human studies. Such effects may have an impact on metabolically stressed cows. Objective: To study the effects of cinnamon supplementation during the transition from late pregnancy to early lactation on the metabolism in dairy cows. Methods: Twenty-four Holstein cows (n = 8/group) were assigned to either the control group (CTR; without supplementation) or the supplementation groups [supplemental cinnamon at 20 (LCIN) or 40 (HCIN) g/cow per day (d)] from 28 d before calving until 21 d thereafter. Blood samples were assayed for glucose, nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), and insulin; an index estimating insulin sensitivity (RQUICKI) was calculated. The serum metabolome was characterized in the samples collected from d 14 using a non-targeted approach. Results: The serum concentrations of glucose and insulin did not differ among groups and followed a similar pattern over time. The serum NEFA concentrations were greater in LCIN (d 2, 7, and 14) and HCIN (d 14) than in CTR. On d 14 and 21, LCIN and HCIN had greater serum BHBA concentrations than CTR cows. The top 10 metabolites identified with significantly higher levels in the supplemented than the CTR cows were related to fatty acid metabolism. Conclusion: The data suggest lipolytic and ketogenic effects of cinnamon supplementation in dairy cows during the transition from late gestation to early lactation. The fatty acid metabolites found elevated in the supplemented cows point towards impaired mitochondrial fatty acid β-oxidation.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cinnamon ; Insulin Resistance ; Metabolite Profile ; Periparturient Cow; Rumen Microbial Fermentation; Essential Oils; Glucose-tolerance; Milk-production; Dose-response; Metabolism; Acid; Cinnamaldehyde; Sensitivity; Performance

ISSN (print) / ISBN 1573-3882

e-ISSN 1573-3890

Journal Metabolomics

Quellenangaben Volume: 13, Issue: 3, Article Number: 28

Publisher Springer

Publishing Place New York, NY

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)