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Bardot, E.* ; Calderon, D.* ; Santoriello, F.* ; Han, S.* ; Cheung, K.* ; Jadhav, B.* ; Burtscher, I. ; Artap, S.* ; Jain, R.K.* ; Epstein, J.A.* ; Lickert, H. ; Gouon-Evans, V.* ; Sharp, A.J.* ; Dubois, N.C.*

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Nat. Commun. 8:14428 (2017)
Publ. Version/Full Text Research data Research data DOI PMC
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The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development. Importantly, Foxa2+ cells contribute to previously identified progenitor populations in a defined pattern and ratio. Lastly, we describe an analogous Foxa2+ population during differentiation of embryonic stem cells. Together, these findings provide insight into the developmental origin of ventricular and atrial cells, and may lead to the establishment of new strategies for generating chamber-specific cell types from pluripotent stem cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Stem-cell Differentiation; Primitive Streak; Heart Development; Myocardial-cells; Mammalian Heart; Mouse Heart; Expression; Morphogenesis; Endoderm; Field
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 14428 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502300-001
PubMed ID 28195173
DOI 10.1038/ncomms14428
WOS ID WOS:000393856600001
Scopus ID 85012936376
Erfassungsdatum 2017-03-23
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