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Schnitzler, M.M.Y.* ; Storch, U.* ; Gudermann, T.

Mechanosensitive G(q/11) protein-coupled receptors mediate myogenic vasoconstriction.

Microcirc. 23, 621-625 (2016)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Myogenic vasoconstriction (Bayliss effect) is mediated by vascular smooth muscle cells (VSMCs) of small resistance arteries sensing mechanical forces. During the last three decades, several proteins have been proposed as VSMC mechanosensors. Our previous studies highlighted agonist-independent mechanical activation of G(q/11) protein-coupled receptors (G(q/11)PCRs) in VSMCs of resistance arteries. In particular, angiotensin II AT1 receptors (AT(1)Rs) emerged as mechanosensors mediating myogenic tone. Moreover, we found that the AT(1B) receptor isoform was more mechanosensitive than the AT(1A) receptor. Interestingly, cysteinyl leukotriene 1 receptors (CysLT(1)Rs) were up-regulated in AT(1)R-deficient arteries as an essential backup strategy to compensate for the loss of vasoconstrictor receptors. Up-regulation of CysLT(1)Rs resulted in increased myogenic tone at low intraluminal pressures resulting in hyperactivity of AT(1)R-deficient arteries. Only at high intraluminal pressures myogenic tone was reduced, thus reflecting the loss of AT(1)Rs. Further, CysLT(1)Rs were involved in myogenic vasoconstriction of wild-type arteries. Simultaneous blockade of AT(1)Rs and CysLT(1)Rs in wild-type arteries caused reduction in myogenic tone of more than 60% comparable to the application of the selective G(q/11)protein inhibitor YM-254890. Our findings suggest that AT(1)Rs and CysLT(1)Rs are crucial mechanosensors in resistance arteries mediating 60% of myogenic vasoconstriction via the G(q/11)-protein pathway without involvement of endogenous agonists.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Gpcrs ; Mechanosensation ; Myogenic Vasoconstriction; Angiotensin-ii; Type-1 Receptor; Pressure; Mouse; Gene; Activation; Inhibitor; Channels; Arteries; Cells
ISSN (print) / ISBN 1073-9688
e-ISSN 1549-8719
Journal Microcirculation
Quellenangaben Volume: 23, Issue: 8, Pages: 621-625 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Malden, Mass.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)