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Time-specific effects of spindle positioning on embryonic progenitor pool composition and adult neural stem cell seeding.
Neuron 93, 777-791.e3 (2017)
The developmental mechanisms regulating the number of adult neural stem cells (aNSCs) are largely unknown. Here we show that the cleavage plane orientation in murine embryonic radial glia cells (RGCs) regulates the number of aNSCs in the lateral ganglionic eminence (LGE). Randomizing spindle orientation in RGCs by overexpression of Insc or a dominant-negative form of Lgn (dnLgn) reduces the frequency of self-renewing asymmetric divisions while favoring symmetric divisions generating two SNPs. Importantly, these changes during embryonic development result in reduced seeding of aNSCs. Interestingly, no effects on aNSC numbers were observed when Insc was overexpressed in postnatal RGCs or aNSCs. These data suggest a new mechanism for controlling aNSC numbers and show that the role of spindle orientation during brain development is highly time and region dependent.
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3.223
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Insc ; Lgn ; Sez ; Adult Neural Stem Cells ; Division Plane ; Radial Glial Cells ; Short Neural Precursor; Subventricular Zone; In-vivo; Olfactory-bulb; Vascular Niche; Self-renewal; Neuroepithelial Cells; Planar Divisions; Radial Glia; Par-complex; Neurogenesis
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0896-6273
e-ISSN
1097-4199
Journal
Neuron
Quellenangaben
Volume: 93,
Issue: 4,
Pages: 777-791.e3
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
PubMed ID
28231465
WOS ID
WOS:000396429100010
Scopus ID
85013632002
Erfassungsdatum
2017-04-04