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Warren, H.R.* ; Evangelou, E.* ; Cabrera, C.P.* ; Gao, H.* ; Ren, M.* ; Mifsud, B.* ; Ntalla, I.* ; Surendran, P.* ; Liu, C.* ; Cook, J.P.* ; Kraja, A.T.* ; Drenos, F.* ; Loh, M.* ; Verweij, N.* ; Marten, J.* ; Karaman, I.* ; Lepe, M.P.* ; O'Reilly, P.F.* ; Knight, J.* ; Snieder, H.* ; Kato, N.* ; He, J.* ; Tai, E.S.* ; Said, M.A.* ; Porteous, D.J.* ; Alver, M.* ; Poulter, N.* ; Farrall, M.* ; Gansevoort, R.T.* ; Padmanabhan, S.* ; Mägi, R.* ; Stanton, A.* ; Connell, J.* ; Bakker, S.J.* ; Metspalu, A.* ; Shields, D.C.* ; Thom, S.* ; Brown, M.* ; Sever, P.* ; Esko, T.* ; Hayward, C.* ; van der Harst, P.* ; Saleheen, D.* ; Chowdhury, R.* ; Chambers, J.C.* ; Chasman, D.I.* ; Chakravarti, A.* ; Newton-Cheh, C.* ; Lindgren, C.M.* ; Levy, D.* ; Kooner, J.S.* ; Keavney, B.* ; Tomaszewski, M.* ; Samani, N.J.* ; Howson, J.M.M.* ; Tobin, M.D.* ; Munroe, P.B.* ; Ehret, G.B.* ; Wain, L.V.* ; ICBP Consortium (Ried, J.S. ; Gieger, C. ; Peters, A.)

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Nat. Genet. 49, 403-415 (2017)
Postprint DOI PMC
Open Access Green
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Coronary-artery-disease; Endothelial-cell; Myocardial-infarction; Neurotrophic Factor; Nadph Oxidase; Uk Biobank; Key Role; In-vivo; Hypertension; Common
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 49, Issue: 3, Pages: 403-415 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-504091-004
G-504000-010
G-504091-001
G-504000-001
DOI 10.1038/ng.3768
WOS ID WOS:000394917800014
Scopus ID 85010952930
PubMed ID 28135244
Erfassungsdatum 2017-03-09
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