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Klar, K.* ; Perchermeier, S.* ; Bhattacharjee, S.* ; Harb, H.* ; Adler, T. ; Istvanffy, R.* ; Loffredo-Verde, E.* ; Oostendorp, R.* ; Renz, H.* ; Prazeres da Costa, C.U.*

Chronic schistosomiasis during pregnancy epigenetically reprograms T cell differentiation in offspring of infected mothers.

Eur. J. Immunol. 47, 841-847 (2017)

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Schistosomiasis is a non-transplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B cell and T cell development. Therefore, we focused our analysis on T cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here we show that naïve T cells from offspring of schistosome infected female mice had a strong capacity to differentiate into TH 1 cells, whereas TH 2 differentiation was impaired. In accordance, reduced levels of histone acetylation of the IL-4 promoter regions were observed in naïve T cells. To conclude, our mouse model revealed distinct epigenetic changes within the naïve T cell compartment affecting TH 2 and TH 1 cell differentiation in offspring of mothers with chronic helminth infection. These findings could eventually help understand how helminths alter T cell driven immune responses induced by allergens, bacterial or viral infections, as well as vaccines.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Epigenetic Histone Modification ; In Utero Programming ; Maternal Helminth Infection ; Schistosomiasis ; T Cell Differentiation; Plasmacytoid Dendritic Cells; Hiv-1 Antigen Presentation; Dc-sign; Innate Immunity; Maturation; Samhd1; Blood; Transmission; Lymphocytes; Activation

ISSN (print) / ISBN 0014-2980

e-ISSN 1521-4141

Journal European Journal of Immunology

Quellenangaben Volume: 47, Issue: 5, Pages: 841-847

Publisher Wiley

Publishing Place Hoboken

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Lung Health and Immunity (LHI)