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Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.
Chem. Soc. Rev. 46, 2158-2198 (2017)
Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.
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38.618
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165
201
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Resolution Photoacoustic Microscopy; Infrared Fluorescent Proteins; Multifunctional Reporter Gene; Targeted Photothermal Therapy; Copper Sulfide Nanoparticles; Walled Carbon Nanotubes; Hand-held Probe; Real-time; Contrast Agents; Gold Nanorods
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0306-0012
e-ISSN
1460-4744
Journal
Chemical Society reviews
Quellenangaben
Volume: 46,
Issue: 8,
Pages: 2158-2198
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505590-001
WOS ID
WOS:000399389600006
Scopus ID
85018468266
PubMed ID
28276544
Erfassungsdatum
2017-04-25