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Hybrid microscopy of human carotid atheroma by means of optical-resolution optoacoustic and non-linear optical microscopy.
Proc. SPIE 10064:1006455 (2017)
Carotid atheromatosis is causally related to stroke, a leading cause of disability and death. We present the analysis of a human carotid atheroma using a novel hybrid microscopy system that combines optical-resolution optoacoustic (photoacoustic) microscopy and several non-linear optical microscopy modalities (second and third harmonic generation, as well as, two-photon excitation fluorescence) to achieve a multimodal examination of the extracted tissue within the same imaging framework. Our system enables the label-free investigation of atheromatous human carotid tissue with a resolution of about 1 μm and allows for the congruent interrogation of plaque morphology and clinically relevant constituents such as red blood cells, collagen, and elastin. Our data reveal mutual interactions between blood embeddings and connective tissue within the atheroma, offering comprehensive insights into its stage of evolution and severity, and potentially facilitating the further development of diagnostic tools, as well as treatment strategies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Human carotid atheroma, Collagen, Red blood cells, Multimodal microscopy, Optoacoustic microscopy, Photoacoustic microscopy, Non-linear optical microscopy
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2017
Conference Date
28 January 2017
Conference Location
San Francisco, California, United States
Journal
Proceedings of SPIE
Quellenangaben
Volume: 10064,
Article Number: 1006455
Publisher
SPIE
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
G-505593-001
G-505593-001
Scopus ID
85018870175
Erfassungsdatum
2017-03-20