PuSH - Publication Server of Helmholtz Zentrum München: Hybrid microscopy of human carotid atheroma by means of optical-resolution optoacoustic and non-linear optical microscopy.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Seeger, M. ; Karlas, A. ; Soliman, D. ; Pelisek, J.* ; Ntziachristos, V.

Hybrid microscopy of human carotid atheroma by means of optical-resolution optoacoustic and non-linear optical microscopy.

Proc. SPIE 10064:1006455 (2017)

Postprint

DOI

	Open Access Green

Abstract
Metrics
Extra information

Carotid atheromatosis is causally related to stroke, a leading cause of disability and death. We present the analysis of a human carotid atheroma using a novel hybrid microscopy system that combines optical-resolution optoacoustic (photoacoustic) microscopy and several non-linear optical microscopy modalities (second and third harmonic generation, as well as, two-photon excitation fluorescence) to achieve a multimodal examination of the extracted tissue within the same imaging framework. Our system enables the label-free investigation of atheromatous human carotid tissue with a resolution of about 1 μm and allows for the congruent interrogation of plaque morphology and clinically relevant constituents such as red blood cells, collagen, and elastin. Our data reveal mutual interactions between blood embeddings and connective tissue within the atheroma, offering comprehensive insights into its stage of evolution and severity, and potentially facilitating the further development of diagnostic tools, as well as treatment strategies.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Human carotid atheroma, Collagen, Red blood cells, Multimodal microscopy, Optoacoustic microscopy, Photoacoustic microscopy, Non-linear optical microscopy

ISSN (print) / ISBN 0277-786X

e-ISSN 1996-756X

Conference Title Photons Plus Ultrasound: Imaging and Sensing 2017

Conference Date 28 January 2017

Conference Location San Francisco, California, United States

Journal Proceedings of SPIE

Quellenangaben Volume: 10064, Article Number: 1006455

Publisher SPIE

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)