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Filippini, T.* ; Michalke, B. ; Grill, P. ; Malagoli, C.* ; Malavolti, M.* ; Vescovi, L.* ; Sieri, S.* ; Krogh, V.* ; Cherubini, A.* ; Maffeis, G.* ; Lucchini, R.* ; Ferrante, M.* ; Vinceti, M.*

Determinants of serum manganese levels in an Italian population.

Mol. Med. Report 15, 3340-3349 (2017)
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Manganese (Mn) is both essential and toxic for humans, mainly depending on the total levels and its species. Main sources of exposure include food and air pollution, particularly motorized traffic. We sought to determine the potential influence of these sources on serum total levels of Mn and Mn species. We selected a random sample of municipality residents from an Italian urban municipality, from whom we collected detailed personal information, dietary habits and a blood sample for serum Mn determination. We also assessed outdoor air Mn exposure, by modeling levels of particulate matter ≤10 µm (PM10) from motorized traffic at the residence of geocoded subjects. Serum Mn species generally showed higher levels in males and positive correlation with age, while no such differences were found according to smoking habits or use of dietary supplements. Among nutrients, only iron intake showed a relation with Mn [an inverse correlation with Mn‑ferritin (Mn‑Fer) and a direct one with inorganic‑Mn (Inorg‑Mn)]. Meat consumption directly correlated and fish and seafood inversely correlated with total Mn, Mn‑transferrin (Mn‑Tf) and Mn-citrate (Mn-Cit). Fruits and vegetables, including legumes and nuts, generally showed a positive correlation with all Mn species, especially Mn‑Cit, and an inverse one with Inorg‑Mn. Odds ratios (ORs) of having serum Mn levels above median value increased with increasing PM10 tertiles, with an OR for highest‑to‑lowest tertile of 7.40 (1.36‑40.25) in multivariate analysis. Analyses for Mn species did not highlight a clear comparable pattern. In conclusion, our results seem to demonstrate that PM10 exposure positively influences total Mn serum levels, while single Mn species show conflicting results.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cross-sectional Study ; Environmental Exposure ; Manganese ; Particulate Matter ; Serum ; Speciation Analysis; Atomic-absorption-spectrometry; Amyotrophic-lateral-sclerosis; Airborne Particulate Matter; Trace-elements; Reference Values; Metal Concentrations; Norwegian Women; Blood-samples; Heavy-metals; Icp-ms
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1791-2997
e-ISSN 1791-3004
Journal Molecular medicine reports
Quellenangaben Volume: 15, Issue: 5, Pages: 3340-3349 Article Number: , Supplement: ,
Publisher Spandidos Publ.
Publishing Place Athens
Reviewing status Peer reviewed
Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
PSP Element(s) G-504800-002
DOI 10.3892/mmr.2017.6379
WOS ID WOS:000401068700127
Scopus ID 85018677035
PubMed ID 28339021
Erfassungsdatum 2017-06-12
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