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Control of hepatitis B virus by cytokines.
Viruses 9:18 (2017)
Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.
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Times Cited
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3.465
1.018
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65
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Publication type
Article: Journal article
Document type
Review
Keywords
Hepatitis B Virus (hbv) ; Cytokine ; Interferon ; Interferon-induced Gene (isg) ; Cccdna ; Therapy; Chronic Hcv Infection; Plasma Half-life; T-cells; Viral-rna; Polyethylene-glycol; Protein-synthesis; Gene-expression; Transgenic Mice; Core Promoter; Mouse Model
Language
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1999-4915
e-ISSN
1999-4915
Journal
Viruses
Quellenangaben
Volume: 9,
Issue: 1,
Article Number: 18
Publisher
MDPI
Publishing Place
Basel
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Immune Response and Infection
PSP Element(s)
G-502700-003
PubMed ID
PMC5294987
DOI
10.3390/v9010018
WOS ID
WOS:000396476200017
Scopus ID
85010830980
Erfassungsdatum
2017-06-01