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Control of hepatitis B virus by cytokines.
Viruses 9:18 (2017)
Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hepatitis B Virus (hbv) ; Cytokine ; Interferon ; Interferon-induced Gene (isg) ; Cccdna ; Therapy; Chronic Hcv Infection; Plasma Half-life; T-cells; Viral-rna; Polyethylene-glycol; Protein-synthesis; Gene-expression; Transgenic Mice; Core Promoter; Mouse Model
ISSN (print) / ISBN
1999-4915
e-ISSN
1999-4915
Journal
Viruses
Quellenangaben
Volume: 9,
Issue: 1,
Article Number: 18
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)