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Ferroptosis inhibition: Mechanisms and opportunities.
Trends Pharmacol. Sci. 38, 489-498 (2017)
The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable attention owing to its putative involvement in diverse pathophysiological processes. A key feature of the ferroptosis process is the requirement of phospholipid peroxidation, a process that has been linked with several human pathologies. Now with the establishment of a connection between lipid peroxidation and a distinctive cell death pathway, the search for new small molecules able to suppress lipid peroxidation has gained momentum and may yield novel cytoprotective strategies. We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of suppressing ferroptosis-relevant cell death and related pathologies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cell Death ; Cysteine Metabolism ; Glutathione Peroxidase ; Lipid Peroxidation ; Regulated Necrosis ; Small Molecules; Glutathione-peroxidase 4; Polyunsaturated Fatty-acids; Chain-breaking Antioxidants; Nonapoptotic Cell-death; Vitamin-e; Parkinsons-disease; Oxidative Stress; Huntingtons-disease; Mouse Model; Alox15 Gene
ISSN (print) / ISBN
0165-6147
e-ISSN
1873-3735
Quellenangaben
Volume: 38,
Issue: 5,
Pages: 489-498
Publisher
Cell Press
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)