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Nathan, S.R.* ; Pino, N.W.* ; Arduino, D.M. ; Perocchi, F. ; MacMillan, S.N.* ; Wilson, J.J.N.*

Synthetic methods for the preparation of a functional analogue of Ru360, a potent inhibitor of mitochondrial calcium uptake.

Inorg. Chem. 56, 3123-3126 (2017)

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Open Access Green as soon as Postprint is submitted to ZB.

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The mixed-valent oxo-bridged ruthenium complex [(HCO2)(NH3)4Ru(μ-O)Ru(NH3)4(O2CH)]3+, known as Ru360, is a selective inhibitor of mitochondrial calcium uptake. Although this compound is useful for studying the role of mitochondrial calcium in biological processes, its widespread availability is limited because of challenges in purification and characterization. Here, we describe our investigations of three different synthetic methods for the preparation of a functional analogue of this valuable compound. We demonstrate that this analogue, isolated from our procedures, exhibits potent mitochondrial calcium uptake inhibitory properties in permeabilized HeLa cells and in isolated mitochondria.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 0020-1669

e-ISSN 1520-510X

Journal Inorganic Chemistry

Quellenangaben Volume: 56, Issue: 6, Pages: 3123-3126

Publisher American Chemical Society (ACS)

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)