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Wegener, E. ; Oeckinghaus, A.* ; Papadopoulou, N. ; Lavitas, L.* ; Schmidt-Supprian, M.* ; Ferch, U.* ; Mak, T.W.* ; Ruland, J.* ; Heissmeyer, V. ; Krappmann, D.

Essential role for I kappa B kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation

Mol. Cell 23, 13-23 (2006)
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T cell receptor (TCR) signaling to IKB kinase (IKK)/NFKB is controlled by PKC theta-dependent activation of the Carma1, Bcl10, and Malt1 (CBM) complex. Antigen-induced phosphorylation of BcI10 has been reported, but its physiological function is unknown. Here we show that the putative downstream kinase IKK beta is required for initial CBM complex formation. Further, upon engagement of IKK beta/Malt1/Bcl10 with Carma1, IKK beta phosphorylates Bcl10 in the C terminus and thereby interferes with Bcl10/Malt1 association and Bcl10-mediated IKK gamma ubiquitination. Mutation of the IKK beta phosphorylation sites on Bcl10 enhances expression of NF-kappa B target genes IL-2 and TNF alpha after activation of primary T cells. Thus, our data provide evidence that IKK beta serves a dual role upstream of its classical substrates, the I kappa B proteins. While being essential for triggering initial CBM complex formation, IKK beta-dependent phosphorylation of Bcl10 exhibits a negative regulatory role in T cell activation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Molimmuno ; Signaling
Language english
Publication Year 2006
HGF-reported in Year 2006
ISSN (print) / ISBN 1097-2765
e-ISSN 1097-4164
Journal Molecular Cell
Quellenangaben Volume: 23, Issue: 1, Pages: 13-23 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
Research Unit Signaling and Translation (SAT)
Research Unit Molecular Immune Regulation (AMIR)
POF-Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Enabling and Novel Technologies
Immune Response and Infection
PSP Element(s) G-551000-001
G-509800-002
G-501792-001
PubMed ID 16818229
DOI 10.1016/j.molcel.2006.05.027
WOS ID 000239215700002
Scopus ID 33745494351
Erfassungsdatum 2006-07-07
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