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Haedicke, K.* ; Brand, C.* ; Omar, M. ; Ntziachristos, V. ; Reiner, T.* ; Grimm, J.*

Sonophore labeled RGD: A targeted contrast agent for optoacoustic imaging.

Photoacoustics 6, 1-8 (2017)
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Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic imaging using a black hole quencher® (BHQ) dye. The sonophore BHQ-1 exhibited strong, concentration-dependent, optoacoustic signals in phantoms, demonstrating its ideal suitability for optoacoustic imaging. After labeling BHQ-1 with cyclic RGD-peptide, BHQ-1-cRGD specifically bound to αvβ3-integrin expressing glioblastoma cell spheroids in vitro. The excellent optoacoustic properties of BHQ-1-cRGD could furthermore be proven in vivo. Together with this emerging imaging modality, our sonophore labeled small peptide probe offers new possibilities for non-invasive detection of molecular structures with high resolution in vivo and furthers the specificity of optoacoustic imaging. Ultimately, the discovery of tailor-made sonophores might offer new avenues for various molecular optoacoustic imaging applications, similar to what we see with fluorescence imaging.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Black Hole Quencher ; Contrast Agent ; Optoacoustic Imaging ; Photoacoustic Imaging ; Rgd Peptide ; Sonophore
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2213-5979
Journal Photoacoustics
Quellenangaben Volume: 6, Issue: , Pages: 1-8 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
PubMed ID 28393018
DOI 10.1016/j.pacs.2017.03.001
Scopus ID 85016403490
Erfassungsdatum 2017-04-25
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