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Molecular imaging probes for multi-spectral optoacoustic tomography.
Chem. Commun. 53, 4653-4672 (2017)
Multi-Spectral Optoacoustic Tomography (MSOT) merges the power of high-resolution imaging at tissue depths of several millimeters to centimeters with the advantages of optical imaging, in large part by exploiting spectral detection of endogenous molecules in tissue or exogenous photoabsorbing probes. Current advances in fast-tuning laser technology, image reconstruction and spectral detection schemes have yielded real-time optoacoustic (photoacoustic) imaging spanning applications from microscopy to human imaging. This progress has generated an unprecedented need for imaging probes and reporter gene approaches optimized for optoacoustic signal generation. New classes of probes are emerging and create new opportunities for visualizing morphological and pathophysiological features in vivo, in a non-invasive manner. Here we review recent progress in optoacoustic probes and discuss applications and challenges for biological imaging as well as prospects for clinical translation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Photoacoustic Contrast Agent; Surface-plasmon Resonance; Iron-oxide Nanoparticles; Sentinel Lymph-node; Semiconducting Polymer Nanoparticles; Copper Sulfide Nanoparticles; Guided Photothermal Therapy; Ray Computed-tomography; Brain-tumor Delineation; Hollow Gold Nanospheres
ISSN (print) / ISBN
0009-241X
e-ISSN
1364-548X
Journal
Chemical Communications
Quellenangaben
Volume: 53,
Issue: 34,
Pages: 4653-4672
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)