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Gujrati, V. ; Mishra, A. ; Ntziachristos, V.

Molecular imaging probes for multi-spectral optoacoustic tomography.

Chem. Commun. 53, 4653-4672 (2017)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Multi-Spectral Optoacoustic Tomography (MSOT) merges the power of high-resolution imaging at tissue depths of several millimeters to centimeters with the advantages of optical imaging, in large part by exploiting spectral detection of endogenous molecules in tissue or exogenous photoabsorbing probes. Current advances in fast-tuning laser technology, image reconstruction and spectral detection schemes have yielded real-time optoacoustic (photoacoustic) imaging spanning applications from microscopy to human imaging. This progress has generated an unprecedented need for imaging probes and reporter gene approaches optimized for optoacoustic signal generation. New classes of probes are emerging and create new opportunities for visualizing morphological and pathophysiological features in vivo, in a non-invasive manner. Here we review recent progress in optoacoustic probes and discuss applications and challenges for biological imaging as well as prospects for clinical translation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Photoacoustic Contrast Agent; Surface-plasmon Resonance; Iron-oxide Nanoparticles; Sentinel Lymph-node; Semiconducting Polymer Nanoparticles; Copper Sulfide Nanoparticles; Guided Photothermal Therapy; Ray Computed-tomography; Brain-tumor Delineation; Hollow Gold Nanospheres
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0009-241X
e-ISSN 1364-548X
Journal Chemical Communications
Quellenangaben Volume: 53, Issue: 34, Pages: 4653-4672 Article Number: , Supplement: ,
Publisher Royal Society of Chemistry (RSC)
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
G-552000-001
DOI 10.1039/c6cc09421j
WOS ID WOS:000400011700002
Scopus ID 85021693464
PubMed ID 28387781
Erfassungsdatum 2017-04-25
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