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'WNT-er is coming': WNT signalling in chronic lung diseases.
Thorax 72, 746-759 (2017)
Chronic lung diseases represent a major public health problem with only limited therapeutic options. An important unmet need is to identify compounds and drugs that target key molecular pathways involved in the pathogenesis of chronic lung diseases. Over the last decade, there has been extensive interest in investigating Wingless/integrase-1 (WNT) signalling pathways; and WNT signal alterations have been linked to pulmonary disease pathogenesis and progression. Here, we comprehensively review the cumulative evidence for WNT pathway alterations in chronic lung pathologies, including idiopathic pulmonary fibrosis, pulmonary arterial hypertension, asthma and COPD. While many studies have focused on the canonical WNT/β-catenin signalling pathway, recent reports highlight that non-canonical WNT signalling may also significantly contribute to chronic lung pathologies; these studies will be particularly featured in this review. We further discuss recent advances uncovering the role of WNT signalling early in life, the potential of pharmaceutically modulating WNT signalling pathways and highlight (pre)clinical studies describing promising new therapies for chronic lung diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Airway Epithelium ; Asthma ; Asthma Mechanisms ; Copd Pharmacology ; Copd ÀÜ Mechanisms ; Cytokine Biology ; Idiopathic Pulmonary Fibrosis; Idiopathic Pulmonary-fibrosis; Airway Smooth-muscle; Wnt/beta-catenin Pathway; Epithelial-mesenchymal Transition; Extracellular-matrix Production; Growth-factor-beta; Arterial-hypertension; Cigarette-smoke; Stem-cells; Tgf-beta
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0040-6376
e-ISSN
1468-3296
Journal
Thorax
Quellenangaben
Volume: 72,
Issue: 8,
Pages: 746-759
Publisher
BMJ Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Research Unit Lung Repair and Regeneration (LRR)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-503100-007
PubMed ID
28416592
WOS ID
WOS:000405401100014
Scopus ID
85024489124
Erfassungsdatum
2017-06-08