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Cord blood metabolome is highly associated with birth weight, but less predictive for later weight development.
Obes. Facts 10, 85-100 (2017)
BACKGROUND/AIMS: Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence. METHODS: Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables. RESULTS: Cord blood metabolites were highly associated with birth weight. Lysophosphatidylcholines C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9, and GPL-FA C22:5n-6 were positively related to birth weight, while higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA C18:3n-3, and PCe C38:0 were associated with lower birth weight. Postnatal weight gain and BMI z-scores in adolescents were not significantly associated with cord blood metabolites after adjustment for multiple testing. CONCLUSION: Potential long-term programming effects of the intrauterine environment and metabolism on later health cannot be predicted with profiling of the cord blood metabolome.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cord Blood ; Metabolomics ; Early Programming ; Childhood Obesity; Performance Liquid-chromatography; Ischemic-heart-disease; Childhood Obesity; Fatty-acids; Tof-ms; Plasma; Growth; Mass; Nutrition; Serum
ISSN (print) / ISBN
1662-4025
e-ISSN
1662-4033
Journal
Obesity Facts
Quellenangaben
Volume: 10,
Issue: 2,
Pages: 85-100
Publisher
Karger
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)