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Open Access Green as soon as Postprint is submitted to ZB.
Epigenetic regulation of glucose metabolism.
Curr. Opin. Clin. Nutr. Metab. Care 20, 266-271 (2017)
PURPOSE OF REVIEW: Glucose metabolism is a central process in mammalian energy homeostasis. Its deregulation is a key factor in development of metabolic disease like diabetes and cancer. In recent decades, our understanding of gene regulation at the signaling, chromatin and posttranscriptional levels has seen dramatic developments. RECENT FINDINGS: A number of epigenetic mechanisms that do not affect the genetic code can be assessed with new technologies. However, increasing complexity becomes a major challenge for translation into clinical application. SUMMARY: The current review provides an update of transcriptional control of glucose metabolism, focusing on epigenetic regulators, DNA-methylation, histone modifications and noncoding RNAs. Recent studies heavily support the importance of those mechanisms for future therapeutics and preventive efforts for metabolic diseases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Dna Methylation ; Epigenetics ; Glucose Metabolism ; Histone Modification ; Noncoding Rna; Epigenome-wide Association; Type-2 Diabetes-mellitus; Long Noncoding Rna; Dna Methylation; Maternal Hyperglycemia; Insulin-resistance; Peripheral-blood; Glycemic Traits; Susceptibility; Identification
ISSN (print) / ISBN
1363-1950
e-ISSN
1473-6519
Quellenangaben
Volume: 20,
Issue: 4,
Pages: 266-271
Publisher
Lippincott Williams & Wilkins
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)