PuSH - Publication Server of Helmholtz Zentrum München: Clinical phenotypes and endophenotypes of atopic dermatitis: Where are we, and where should we go?

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Bieber, T.* ; D'Erme, A.M.* ; Akdis, C.A.* ; Traidl-Hoffmann, C. ; Lauener, R.* ; Schappi, G.* ; Schmid-Grendelmeier, P.*

Clinical phenotypes and endophenotypes of atopic dermatitis: Where are we, and where should we go?

J. Allergy Clin. Immunol. 139, S58-S64 (2017)

Publ. Version/Full Text

DOI

PMC

	Free by publisher

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Atopic dermatitis (AD) is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology and a wide spectrum of the clinical phenotype. Despite this high degree of heterogeneity, ADis still considered a single disease and usually treated according to the "one-size-fits-all'' approach. Thus more tailored prevention and therapeutic strategies are still lacking. As for other disciplines, such as oncology or rheumatology, we have to approach AD in a more differentiated way (ie, to dissect and stratify the complex clinical phenotype into more homogeneous subgroups based on the endophenotype [panel of biomarkers]) with the aim to refine the management of this condition. Because we are now entering the era of personalized medicine, a systems biology approach merging the numerous clinical phenotypes with robust (ie, relevant and validated) biomarkers will be needed to best exploit their potential significance for the future molecular taxonomy of AD. This approach will not only allow an optimized prevention and treatment with the available drugs but also hopefully help assign newly developed medicinal products to those patients who will have the best benefit/risk ratio.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Atopic Dermatitis ; Clinical Phenotype ; Endophenotype ; Biomarkers ; Stratified Medicine ; Precision Medicine; Thymic Stromal Lymphopoietin; Precision Medicine; Barrier Impairment; Allergic Diseases; Adult Patients; Skin Barrier; Food Allergy; Biomarkers; Association; Filaggrin

ISSN (print) / ISBN 0091-6749

e-ISSN 1097-6825

Journal The journal of allergy and clinical immunology

Quellenangaben Volume: 139, Issue: 4, Pages: S58-S64

Publisher Elsevier

Publishing Place Amsterdam [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Environmental Medicine (IEM)