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Open Access Green as soon as Postprint is submitted to ZB.
Therapeutic vaccination for chronic hepatitis B.
Curr. Opin. Virol. 23, 75-81 (2017)
A therapeutic vaccine is meant to activate the patient's immune system to fight and finally control or ideally eliminate an already established infectious pathogen. Whereas the success of prophylactic vaccination is based on rapid antibody-mediated neutralization of an invading pathogen, control and elimination of persistent viruses such as hepatitis, herpes or papilloma viruses requires multi-specific and polyfunctional effector T cell responses. These are ideally directed against continuously expressed viral antigens to keep the pathogen in check. Activation of a humoral immune response in order to lower viral antigen load and to limit virus spread, however, confers an additional benefit. Therapeutic vaccines are under development for a number of chronic infections and require an intelligent vaccine design. Hepatitis B virus (HBV) infection may serve as a prime example since a spontaneous, immune-mediated recovery of chronic hepatitis B and an elimination of the virus is possible even if it is observed only in very rare cases. In this review, we summarize the current knowledge and potential improvements of therapeutic vaccines for chronic hepatitis B.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Vaccinia Virus Ankara; Hbv-transgenic Mice; T-cell Responses; Boost Vaccination; Viral-hepatitis; Hepatocellular-carcinoma; Nonviral Delivery; Suppressor-cells; Immune-responses; Surface-antigen
ISSN (print) / ISBN
1879-6257
e-ISSN
1879-6265
Journal
Current Opinion in Virology
Quellenangaben
Volume: 23,
Pages: 75-81
Publisher
Elsevier
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)